If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. You may also experience withdrawal symptoms.
As with all opioid drugs, it is necessary to adjust the dosing regimen for each patient individually, taking into account the patient's prior analgesic treatment experience. The following dosing recommendations should only Beryllium considered as suggested approaches to what is actually a series of clinical decisions over time hinein the management of the pain of each individual patient.
If you take too much methadone hydrochloride tablets or overdose, call 911 or your local emergency number right away.
Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result hinein toxic effects.
Acute Pain – Maintenance patients on a stable dose of methadone Weltgesundheitsorganisation experience physical trauma, postoperative pain or other acute pain cannot be expected to derive analgesia from their existing dose of methadone. Such patients should Beryllium administered analgesics, including opioids, rein doses that would otherwise Beryllium indicated for non-methadone-treated patients with similar painful conditions.
Patients developing QT prolongation while on methadone treatment should Beryllium evaluated for the presence of modifiable risk factors, such as concomitant medications with cardiac effects, drugs which might cause electrolyte abnormalities, and drugs which might act as inhibitors of methadone metabolism. For use of methadone to treat pain, the risk of QT prolongation and development of dysrhythmias should Beryllium weighed against the benefit of adequate pain management Erhaltungstherapie mit Methadontabletten and the availability of alternative therapies.
The content rein this section is aimed at anyone involved in planning, implementing or making decisions about health and social responses.
Do not take a higher dose of methadone hydrochloride tablets or take it more often than prescribed. This can lead to an overdose and possible death.
Opioid antagonists should not be administered hinein the absence of clinically significant respiratory or cardiovascular depression. In an individual physically dependent on opioids, the administration of the usual dose of an opioid antagonist may precipitate an acute withdrawal syndrome.
Patients and their caregivers should Beryllium advised to discard unused methadone rein such a way that individuals other than the patient for whom it welches originally prescribed will not come rein contact with the drug.
for maintenance treatment of narcotic drug addiction along with other social and medical services. Stopping maintenance treatment of narcotic drug addiction with methadone hydrochloride tablets may result rein a return to narcotic drug use.
Overdose hinein children warning: Children World health organization accidentally take this drug have a high risk of death from overdosing. Children should not take this drug.
The following drug interactions were reported following coadministration of methadone with inducers of cytochrome P450 enzymes:
There is considerable variability in the appropriate Tarif of methadone taper rein patients choosing medically supervised withdrawal from methadone treatment. It is generally suggested that dose reductions should be less than 10% of the established tolerance or maintenance dose, and that 10 to 14-day intervals should elapse between dose reductions.